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Synlett 1995; 1995(11): 1097-1109
DOI: 10.1055/s-1995-5191
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Biochemical Methods in Enantioselective Synthesis of Bioactive Natural Products

Kenji Mori*
  • *Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162, Japan, Fax 81-3-3235-2214
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Publication History

Publication Date:
31 December 2000 (online)

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Hydrolytic enzymes and microorganisms were employed in enantioselective syntheses of bioregulators such as hormones and pheromones. Esterases and lipases were useful in achieving optical resolution, conversion of meso-compounds to optically active compounds, and macrolactonization. Yeasts provided a variety of optically active hydroxy ketones and esters, which served as versatile non-racemic chiral building blocks.

Building blocks - esterases - lipases - yeasts